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Abstract
ABSTRACT
Hypertension is one of the degenerative disease of health problem in among people.
Bilimbi leaves (Averrhoa bilimbi L.) is one of plants which is have antihypertension effect and
contains phytol, dietil phtalat, flavonoid. This research is aimed to know influence of ethanol
extract of bilimbi leaves (EEBL)Â Â through its on the increase of the antihypertensive effect of
captopril in hypertensive rats.
This research used a pre-test and post-test matched control group design.  Sample were 30
male Wistar rats treated with MSG 100 mg/kgBW/day (po) for 14 days to induce hypertension.
Hypertensive rats were divided into six treatment groups are hypertension control group (0.5%
CMC-Na 12.5 mL/kgBW/day) and positive control group (captopril 2.5 mg/kgBW/day), and
treatment hypertensive rats EEBL (60 and 120) mg/kgBW/day, combination of EEBL-captopril
(60+2.5)mg/kgBW/day and combination EEBL-captopril (120+2.5) mg/kgBW/day. Suspension
test were given for 14 days. Observed data is a decrease in blood pressure after giving of the
suspension test. Data analysis was performed with the parametric t-test paired and nonparametric
Wilcoxon with 95% level of confidence.
The result shows that MSG can be as inducer of hypertension. EEBL (60 and 120)
mg/kgBW/day has antihypertensive effect. The increase antihypertensive effect of captopril on
systolic blood pressure is showed in the treatment EEBL 120 mg/kgBW/day. Â
Keywords: Hypertension, Monosodium glutamate, Averrhoa bilimbi L.
Hypertension is one of the degenerative disease of health problem in among people.
Bilimbi leaves (Averrhoa bilimbi L.) is one of plants which is have antihypertension effect and
contains phytol, dietil phtalat, flavonoid. This research is aimed to know influence of ethanol
extract of bilimbi leaves (EEBL)Â Â through its on the increase of the antihypertensive effect of
captopril in hypertensive rats.
This research used a pre-test and post-test matched control group design.  Sample were 30
male Wistar rats treated with MSG 100 mg/kgBW/day (po) for 14 days to induce hypertension.
Hypertensive rats were divided into six treatment groups are hypertension control group (0.5%
CMC-Na 12.5 mL/kgBW/day) and positive control group (captopril 2.5 mg/kgBW/day), and
treatment hypertensive rats EEBL (60 and 120) mg/kgBW/day, combination of EEBL-captopril
(60+2.5)mg/kgBW/day and combination EEBL-captopril (120+2.5) mg/kgBW/day. Suspension
test were given for 14 days. Observed data is a decrease in blood pressure after giving of the
suspension test. Data analysis was performed with the parametric t-test paired and nonparametric
Wilcoxon with 95% level of confidence.
The result shows that MSG can be as inducer of hypertension. EEBL (60 and 120)
mg/kgBW/day has antihypertensive effect. The increase antihypertensive effect of captopril on
systolic blood pressure is showed in the treatment EEBL 120 mg/kgBW/day. Â
Keywords: Hypertension, Monosodium glutamate, Averrhoa bilimbi L.