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June 24, 2016
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June 1, 2016
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Abstract
ABSTRACT
Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus
indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental
study was to investigate the antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and
angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea
method. The study design is a randomized matched two group post test-only. JLEE and ALEE
produced by maceration. An antidiarrheal activity of both of extracts compared with loperamide-
HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg
BW significantly (p <0.05) decrease the amount of liquid and soft feces, and delay the onset of
diarrhea compared with controls (NaCl 0.9% 10 mL/Kg BW). The ability JLEE 400 mg/Kg BW
and EEDA 320 mg/Kg BW on inhibiting the formation liquid and soft feces are higher than
loperamide HCl 10 mg/Kg BW with antidiarrheal effect amounted to 72.31%, 65.47%, and
54.46% respectively. The potency of JLEE and ALEE as antidiarrheal (ED50) are (20.85 and 3.52)
mg/Kg BW respectively. However, in this study, a single dose of loperamide-HCl, JLEE and
ALEE treatments are not able to heal the diarrhea symptom (p> 0.05).
Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus
heterophyllus Lam., Pterocarpus indicus Wild.
Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus
indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental
study was to investigate the antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and
angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea
method. The study design is a randomized matched two group post test-only. JLEE and ALEE
produced by maceration. An antidiarrheal activity of both of extracts compared with loperamide-
HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg
BW significantly (p <0.05) decrease the amount of liquid and soft feces, and delay the onset of
diarrhea compared with controls (NaCl 0.9% 10 mL/Kg BW). The ability JLEE 400 mg/Kg BW
and EEDA 320 mg/Kg BW on inhibiting the formation liquid and soft feces are higher than
loperamide HCl 10 mg/Kg BW with antidiarrheal effect amounted to 72.31%, 65.47%, and
54.46% respectively. The potency of JLEE and ALEE as antidiarrheal (ED50) are (20.85 and 3.52)
mg/Kg BW respectively. However, in this study, a single dose of loperamide-HCl, JLEE and
ALEE treatments are not able to heal the diarrhea symptom (p> 0.05).
Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus
heterophyllus Lam., Pterocarpus indicus Wild.