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January 12, 2018
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January 12, 2018
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Abstract
ABSTRACT
Reduced bone density is an indication of osteoporosis. The study of osteoporosis is
conducted by measure the influence of triggering compound to the enhancement of bone density of
ovariectomized rat that have been lifted ovaries. Ovariectomy caused rats have been deficiency of
estrogen hormone whose function to maintain bone density.Compound that can increase bone
density has the potential as osteoporosis drug.
Red ginger rhizome contains flavonoid compound as phytoestrogen whose estrogenic
effect that can replace the function of estrogen. Flavonoid is easy to be solved in ethanol so that
was extracted using ethanol. The purpose of this study was to measure the enhancement of bone
density of ovariectomized rats due to the trigger of ethanol extract of red ginger (EERJM).
Research was conducted experimentally to the female Wistar rats by the post test only
controlled group design. Treatment was given for 30 days and the determination of bone density
using Dual X-Ray radiography method. Data of bone density values were statistically analyzed by
One Way ANOVA followed by Tukey test. The results showed that the administration of EERJM
dose 500 and 1000 mg/kg BW enhanced bone density of ovariectomized rat.
Keywords: bone density, ovariectomized rat, red ginger, osteoporosis
Reduced bone density is an indication of osteoporosis. The study of osteoporosis is
conducted by measure the influence of triggering compound to the enhancement of bone density of
ovariectomized rat that have been lifted ovaries. Ovariectomy caused rats have been deficiency of
estrogen hormone whose function to maintain bone density.Compound that can increase bone
density has the potential as osteoporosis drug.
Red ginger rhizome contains flavonoid compound as phytoestrogen whose estrogenic
effect that can replace the function of estrogen. Flavonoid is easy to be solved in ethanol so that
was extracted using ethanol. The purpose of this study was to measure the enhancement of bone
density of ovariectomized rats due to the trigger of ethanol extract of red ginger (EERJM).
Research was conducted experimentally to the female Wistar rats by the post test only
controlled group design. Treatment was given for 30 days and the determination of bone density
using Dual X-Ray radiography method. Data of bone density values were statistically analyzed by
One Way ANOVA followed by Tukey test. The results showed that the administration of EERJM
dose 500 and 1000 mg/kg BW enhanced bone density of ovariectomized rat.
Keywords: bone density, ovariectomized rat, red ginger, osteoporosis