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January 12, 2018
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January 12, 2018
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Abstract
ABSTRACT
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The aim of this study was to investigate the subchronic toxicity of extract of papaya seed
(Carica papaya L.) on rat by evaluate Serum Glutamic Pyruvic Transaminase (SGPT)
and Serum Glutamic Oxaloasetic Transaminase (SGOT) activity. Twenty (20) white male
miceswere randomly grouped into four groups (one control and three treatment groups).
Group 1 received 1% of CMCNa. Group 2, 3, and 4 received extract of papaya seed at a
dose of 50 mg/kg body weight, 500 mg/kg body weight, and 5000 mg/kg body weight.
After 28 days treatment, blood samples were collected from jugular vein near the eye to
evaluate SGPT and SGOT level in serum. Data were analyzed using ANOVA (at 95%
confidence). It is observed that extract of papaya seed at a dose 50 mg/kg body weight,
500 mg/ kg body weight, and 5000 mg/kg body weight have no effect to increase SGPT
and SGOT activity. Â
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Key Word : Papaya Seed,Subacute, Toxicity, SGPT, SGOT
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The aim of this study was to investigate the subchronic toxicity of extract of papaya seed
(Carica papaya L.) on rat by evaluate Serum Glutamic Pyruvic Transaminase (SGPT)
and Serum Glutamic Oxaloasetic Transaminase (SGOT) activity. Twenty (20) white male
miceswere randomly grouped into four groups (one control and three treatment groups).
Group 1 received 1% of CMCNa. Group 2, 3, and 4 received extract of papaya seed at a
dose of 50 mg/kg body weight, 500 mg/kg body weight, and 5000 mg/kg body weight.
After 28 days treatment, blood samples were collected from jugular vein near the eye to
evaluate SGPT and SGOT level in serum. Data were analyzed using ANOVA (at 95%
confidence). It is observed that extract of papaya seed at a dose 50 mg/kg body weight,
500 mg/ kg body weight, and 5000 mg/kg body weight have no effect to increase SGPT
and SGOT activity. Â
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Key Word : Papaya Seed,Subacute, Toxicity, SGPT, SGOT