AKTIVITAS ANTIJAMUR KRIM EKSTRAK ETANOL DAUN JAMBU MONYET (Anacardium occidentale L.) DAN KULIT BATANG RAMBUTAN (Nephelium lappaceum) TERHADAP Candida albicans

Abstract

ABSTRACT
Ethanol extract of Anacardium occidentale and rambutan bark  (Nephelium lappaceum) proved to
have antifungal activity agains Candida albicans. Efforts to improve comfort and ease of use then
made in the form of cream formulation.The aim of study is to know the antifungal activity of
cream with various concentration of  Anacardium occidentaleleaf extract and rambutan bark
againstCandida albicans.
Extraction of ethanol extractAnacardium occidentale leaf (EAOL) and  rambutan bark (ERB) used
maceration method. Solvents used ethanol 70% and ethanol 96%, respectively. Formulation cream
of EAOL and ERB was maked 3 formulation.  Formulation cream EAOL with concentration of
variations extract are FI (10,5%), FII (12,5%), FIII (14,5%). Formulation cream ERB with
concentration of varions extract  are FI (10%), FII (15%), FIII (20%).  Antifungal activity was
determined in the cream using agar diffusion method and  zone of inhibitionwere analyzed using
descriptive.
The results showed that  antifungal activity against  Candida albicans  of cream EAOL
concentration 14,5% with zone of inhibition is 7,16 ± 0,28 mm and cream ERB concentration 20%
with zone of inhibition is 9,5 ± 0,5 mm.  
Kata Kunci : Antifungal,  Anacardium occidentale, Nephelium lappaceum,  Formulation
ofcream