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Submitted
July 23, 2020
Published
June 1, 2020
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Abstract
ABSTRACT
Paracetamol is available in oral and rectal formulations for decades. Controversies regarding
conformity of formulations and dosages were found in the use of paracetamol as antipyretic. The
purpose of this research is to know the effectiveness of paracetamol oral administration compared
to the rectal administration for the loss of fever (antipyretic) in children that is systematic review.
Research was done through searches from the database PubMed, NEJM, EBSCO, ProQuest,
Science Direct. Systematic review was done on the child subject that aged 3 months to 13 years old
and 1 month with fever and randomized trial with blind. Trials are examined based on predesigned
inclusion criteria and exclusion criteria. Conducted systematic review and systematic
review of randomized controlled trials was done to determine the effectiveness of the
administration of paracetamol orally compared to the rectally. Data is homogeneous with RR 0.98
(CI 95%: 0.85-1.13). The effectiveness of the rectally compared to the oral administration of
paracetamol is not significantly different in spite of the effectiveness of orally paracetamol amount
of 0.98 times compared to the rectally.
Keywords: antipyretic, child, orally paracetamol, rectally paracetamol
Paracetamol is available in oral and rectal formulations for decades. Controversies regarding
conformity of formulations and dosages were found in the use of paracetamol as antipyretic. The
purpose of this research is to know the effectiveness of paracetamol oral administration compared
to the rectal administration for the loss of fever (antipyretic) in children that is systematic review.
Research was done through searches from the database PubMed, NEJM, EBSCO, ProQuest,
Science Direct. Systematic review was done on the child subject that aged 3 months to 13 years old
and 1 month with fever and randomized trial with blind. Trials are examined based on predesigned
inclusion criteria and exclusion criteria. Conducted systematic review and systematic
review of randomized controlled trials was done to determine the effectiveness of the
administration of paracetamol orally compared to the rectally. Data is homogeneous with RR 0.98
(CI 95%: 0.85-1.13). The effectiveness of the rectally compared to the oral administration of
paracetamol is not significantly different in spite of the effectiveness of orally paracetamol amount
of 0.98 times compared to the rectally.
Keywords: antipyretic, child, orally paracetamol, rectally paracetamol