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January 22, 2021
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January 22, 2021
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Abstract
ABSTRACT
Dyslipidemia is the commonest cause of many atherosclerotic diseases. Statins are the mainstay of
the management of dyslipidemia, and it is widely prescribed for patients in Indonesia. This study
aims to give an overview, the use of statin, and its drug-drug interactions. The study method was
descriptive, using a purposive sampling technic. The inclusion criteria were patients who received
statins therapy, in the outpatient installation of Tugurejo Regional Public Hospital, Semarang,
during April 2017. There were 334 patients meet the inclusion criteria, most of them were women
(63,28%). The highest patients’ range was 60-69 years old of 129 patients (38,62%). One hundred
and thirty-one patients (39,22%) were diagnosed with dyslipidemia only. The dosage range of
simvastatin and rosuvastatin was 10 to 20 mg once daily, but rosuvastatin was only given 10 mg
once daily. The most dose was 10 mg simvastatin per day, prescribed for 231 patients (69,16%).
There were 177 patients (52,99%) who has the potentiate of statin drug interactions. The most
were simvastatin-amlodipine interactions, occurs in 104 patients (31,14%). This study shows that
most statin users are elderly patients. Statin is used not only in dyslipidemia patients. There are
many potential statin drug-drug interactions, but the statin dose is low and not over the standard
doses.
Keyword: dyslipidemia, statins, drug interactions
Dyslipidemia is the commonest cause of many atherosclerotic diseases. Statins are the mainstay of
the management of dyslipidemia, and it is widely prescribed for patients in Indonesia. This study
aims to give an overview, the use of statin, and its drug-drug interactions. The study method was
descriptive, using a purposive sampling technic. The inclusion criteria were patients who received
statins therapy, in the outpatient installation of Tugurejo Regional Public Hospital, Semarang,
during April 2017. There were 334 patients meet the inclusion criteria, most of them were women
(63,28%). The highest patients’ range was 60-69 years old of 129 patients (38,62%). One hundred
and thirty-one patients (39,22%) were diagnosed with dyslipidemia only. The dosage range of
simvastatin and rosuvastatin was 10 to 20 mg once daily, but rosuvastatin was only given 10 mg
once daily. The most dose was 10 mg simvastatin per day, prescribed for 231 patients (69,16%).
There were 177 patients (52,99%) who has the potentiate of statin drug interactions. The most
were simvastatin-amlodipine interactions, occurs in 104 patients (31,14%). This study shows that
most statin users are elderly patients. Statin is used not only in dyslipidemia patients. There are
many potential statin drug-drug interactions, but the statin dose is low and not over the standard
doses.
Keyword: dyslipidemia, statins, drug interactions