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June 29, 2022
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June 30, 2022
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Abstract

Garlic (Allium sativum L.) has various potentials in overcoming diseases, one of which is as an antibacterial. The purpose of this study was to explore, analyze and review the activity of garlic (Allium sativum L.) as an antibacterial agent. This study uses a literature search method using search sites such as Google Scholar, Pubmed, ScienceDirect, AYU, NCBI, Elsevier, PlosOne, and Google Scholar. by entering keywords such as antibacterial, Garlic, and Allium sativum L. Garlic contains secondary metabolites that function as antibacterial agents such as alkaloids, tannins, saponins, flavonoids, allicin. Garlic has been shown to inhibit the growth of gram-positive and negative bacteria species Escherichia, Salmonella, Staphylococcus, Streptococcus, Klebsiella, Proteus, Bacillus, Clostridium, P. aeruginosa, K. pneumoniae and, Bifidobacterium lactis predominantly using the paper disk and well diffusion method.

 

Keywords

Allium sativum L Antibacterial Diffusion Garlic

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References

  1. Abidullah, M., Jadhav, P., Sujan, S.S., Shrimanikandan, A.G., Reddy, C.R., Wasan, R.K., 2021.
  2. Potential Antibacterial Efficacy of Garlic Extract on Staphylococcus aureus, Escherichia coli,
  3. and Klebsiella pneumoniae: An In vitro Study, J Pharm Bioallied Sci, 13(1), 590–594.
  4. Abiy, E., Berhe, A., 2016, Anti-Bacterial Effect of Garlic (Allium sativum) against Clinical Isolates
  5. of Staphylococcus aureus and Escherichia coli from Patients Attending Hawassa Referral
  6. Hospital, Ethiopia. Journal of Infectious Diseases and Treatment, 02(02), 1–5.
  7. Ali, M., Ibrahim, I.S., 2016, Phytochemical Screening and Proximate Analysis of Newbouldia
  8. laevis and Allium sativum. Nigerian Journal of Animal Science, 18(1), 242-256–256.
  9. Alirezaei, S., Godarzi, H., Moezi ghadim, N., Maheri, A., 2019, Antimicrobial Activity of Aqueous
  10. Garlic Extract (Allium sativum) Against Porphyromonas gingivalis: An In-Vitro Study.
  11. Journal of Research in Dental and Maxillofacial Sciences, 4(4), 17–22.
  12. Altuntas, S., Korukluoglu, M., 2019, Growth and effect of garlic (Allium sativum) on selected
  13. beneficial bacteri. Food Science and Technology, 39(4), 897–904.
  14. Anggraini, A.L., Dwiyanti, R.D., Thuraidah, A., 2020, Garlic Extract (Allium sativum L.)
  15. Effectively Inhibits Staphylococcus aureus and Escherichia coli by Invitro Test. Tropical
  16. Health and Medical Research, 2(2), 61–68.
  17. Anyamaobi, O.P., Wokem, G.N., Enweani Bessie, I., Okosa, N.J.A., Opara, C.E., Nwokeji, M.C.,
  18. , Antimicrobial Effect Of Garlic And Ginger On Staphylococcus aureus From Clinical
  19. Specimens In Madonna University Teaching Hospital, Nigeria. International Journal of
  20. Recent Scientific Research, 11(3), 37840–37845.
  21. Batiha, G.E.S., Beshbishy, A.M., Wasef, L.G., Elewa, Y.H.A., Al-Sagan, A.A., El-Hack, M.E.A.,
  22. Taha, A.E., Abd-Elhakim, Y.M., Devkota, H.P., 2020, Chemical constituents and
  23. pharmacological activities of garlic (Allium sativum L.): A review. Nutrients, 12(3), 1–21.
  24. Benmeziane, F., Djermoune-Arkoub, L., Adamou Hassan, K., Zeghad, H., 2018, Evaluation of
  25. antibacterial activity of aqueous extract and essential oil from garlic against some pathogenic
  26. bacteria. International Food Research Journal, 25(2), 561–564.
  27. Bernaldez, J.L., Vicencio, M.C.G., 2021, Antibacterial Activity of Soap Formulated from Garlic
  28. (Allium sativum L.) Extract. Journal of Advances in Microbiology, 21(1), 63–67.
  29. Bhatwalkar, S.B., Mondal, R., Krishna, S.B.N., Adam, J.K., Govender, P., Anupam, R., 2021,
  30. Antibacterial Properties of Organosulfur Compounds of Garlic (Allium sativum). Frontiers in
  31. Microbiology, 12(July), 1–20.
  32. Booyens, J., Thantsha, M.S., 2013, Antibacterial effect of hydrosoluble extracts of garlic (Allium
  33. sativum) against Bifidobacterium spp. and Lactobacillus acidophilus. African Journal of
  34. Microbiology Research, 7(8), 669–677.
  35. Cahayani, W.A., Tanuwijaya, C., Chi, L.X., Mulyastuti, Y., 2019, Antibacterial activity of garlic
  36. (Allium sativum) extract and molecular docking studies of allicin. AIP Conference
  37. Proceedings, 1-6.
  38. Cushnie, T.P.T., Cushnie, B., Lamb, A.J., 2014. Alkaloids: An overview of their antibacterial,
  39. antibiotic-enhancing and antivirulence activities. International Journal of Antimicrobial
  40. Agents, 44(5), 377–386.
  41. Daka, D., 2011, Antibacterial effect of garlic (Allium sativum) on Staphyloccus aureus: An in vitro
  42. study, African Journal of Biotechnology, 10(4), 666–669.
  43. Derbe, T., 2014, Antibacterial Activity Of Garlic Extracts Against Gram-Negative And Gram-
  44. Positive Bacteria Tessema Derbe , Brey Kidane Mariam and Shilashi Badasa Department of
  45. Chemistry, Adigrat University, P.O. box 50, Adigrat, Ethiopia 1(11), 730–734.
  46. Enejiyon, S.O., Abdulrahman, A.A., Adedeji, A.S., 2020, Antibacterial Activities of the Extracts of
  47. Allium sativum (Garlic) and Allium cepa (Onion) Against Selected Pathogenic Bacteria.
  48. Tanzania Journal of Science, 46(3), 914–922.
  49. Fatima, A., Ahmad, T., Khan, S.J., Deeba, F., Zaidi, N., 2011, Assessment of antibacterial activity
  50. of in vitro and in vivo grown garlic (Allium sativum L.), Pakistan Journal of Botany,
  51. (6),33029-22033.
  52. Fowotade, A., Fowotade, A., Enaibe, B., Avwioro, G., 2017, Evaluating Toxicity Profile of Garlic
  53. (Allium sativum) on the Liver, Kidney and Heart Using Wistar Rat Model. International
  54. Journal of Tropical Disease & Health, 26(2), 1–12.
  55. Fufa, B.K., 2019, Anti-bacterial and Anti-fungal Properties of Garlic Extract (Allium sativum): A
  56. Review. Microbiology Research Journal International, 28(3), 1–5.
  57. Garba, I., Umar, A., Abdulrahman, A., Tijjani, M., Aliyu, M., Zango, U., Muhammad, A., 2014,
  58. Phytochemical and antibacterial properties of garlic extracts. Bayero Journal of Pure and
  59. Applied Sciences, 6(2), 45.
  60. Houshmand, B., Mahjour, F., Dianat, O., 2013, Antibacterial effect of different concentrations of
  61. garlic (Allium sativum) extract on dental plaque bacteria. Indian Journal of Dental Research,
  62. (1), 71–75.
  63. Jahani Moghadam, F., Navidifar, T., Amin, M., 2014, Antibacterial Activity of Garlic (Allium
  64. sativum L.) on Multi-Drug Resistant Helicobacter pylori Isolated From Gastric Biopsies.
  65. International Journal of Enteric Pathogens, 2(2), 2–5.
  66. Kshirsagar, M.M., Dodamani, A.S., Khobragade, V.R., 2018, Antibacterial activity of garlic extract
  67. on cariogenic bacteria: An in vitro study, AYU (An International Quarterly Journal of
  68. Research in Ayurveda), 39(3), 165–168.
  69. Lawal, B., Shittu, O.K., Oibiokpa, F.I., Mohammed, H., Umar, S.I., Haruna, G.M., 2016,
  70. Antimicrobial evaluation, acute and sub-acute toxicity studies of Allium sativum. Journal of
  71. Acute Disease, 5(4), 296-301.
  72. Li, G., Ma, X., Deng, L., Zhao, X., Wei, Y., Gao, Z., Jia, J., Xu, J., Sun, C., 2015, Fresh garlic
  73. extract enhances the antimicrobial activities of antibiotics on resistant strains in vitro.
  74. Jundishapur Journal of Microbiology, 8(5), 1–6.
  75. Londhe, V.P., Gavasane, A.T., Nipate, S.S., Bandawane, D.D., Chaudhari, P.D., 2011, Review
  76. Role of Garlic (Allium sativum) in Various Diseases : an Overview. Journal of
  77. Pharmaceutical Research and Opinion, 4(January 2011), 129–134.
  78. Lu, X., Rasco, B.A., Jabal, J.M.F., Eric Aston, D., Lin, M., Konkel, M.E., 2011, Investigating
  79. antibacterial effects of garlic (Allium sativum) concentrate and garlic-derived organosulfur
  80. compounds on Campylobacter jejuni by using fourier transform infrared spectroscopy, Raman
  81. spectroscopy, and electron microscopy. Applied and Environmental Microbiology, 77(15),
  82. –5269.
  83. Mentri Kesehatan Republik Indonesia, 2016, Peraturan Menteri Kesehatan Republik Indonesia
  84. Nomor 6 Tahun 2016 Tentang Formularium Obat Herbal Asli Indonesia, Jakarta: Kementrian
  85. Kesehatan.
  86. Moulia, M.N., Syarief, R., Iriani, E.S., Kusumaningrum, H.D., Suyatma, N.E., 2018, Antimikroba
  87. Ekstrak Bawang Putih, Jurnal Pangan, 27(1), 55–66.
  88. Mozaffari Nejad, A.S., Shabani, S., Bayat, M., Hosseini, S.E., 2014, Antibacterial effect of garlic
  89. aqueous extract on Staphylococcus aureus in hamburger, Jundishapur Journal of
  90. Microbiology, 7(11), 1–5.
  91. Nugraha, S.E., Suryadi Achmad, Erly Sitompul, 2019. Antibacterial Activity of Ethyl Acetate
  92. Fraction of Passion Fruit Peel (Passiflora edulis Sims) on Staphylococcus aureus and
  93. Escherichia Coli, Indonesian Journal of Pharmaceutical and Clinical Research, 2(1), 7–12.
  94. Nurtjahyani, S.D., Hadra, F., 2016, Antibacterial activity of garlic (Allium sativum) againts Gram-
  95. positive bacteria isolated from tiger shrimp (Penaeus monodon), Asian Pacific Journal of
  96. Tropical Disease, 6(1), 46–48.
  97. Patil, P.. and, Pwar, 2016, Antibacterial activity of ginger (Zingiber officinale) and garlic (Allium
  98. sativum L.) extracts on Escherichia coli. International Journal of Advanced Research and
  99. Development, 1(5), 8–11.
  100. Prati, P., Henrique, C.M., Souza, A.S. de, Silva, V.S.N. da, Pacheco, M.T.B., 2014, Evaluation of
  101. allicin stability in processed garlic of different cultivars. Food Science and Technology
  102. (Campinas), 34(3), 623–628.
  103. Prihandani, S.S., 2015, Uji Daya Antibakteri Bawang Putih (Allium sativum L.) terhadap Bakteri
  104. Staphylococcus aureus, Escherichia coli, Salmonella typhimurium dan Pseudomonas
  105. aeruginosa dalam Meningkatkan Keamanan Pangan, Informatika Pertanian, 24(1), 53.
  106. Purwantiningsih, T.I., Rusae, A., Freitas, Z., 2019. Uji In Vitro Antibakteri Ekstrak Bawang Putih
  107. sebagai Bahan Alami untuk Menghambat Bakteri Staphylococcus aureus dan Escherichia
  108. coli, Sains Peternakan, 17(1), 1–4.
  109. Ratthawongjirakul, P., Thongkerd, V., 2016, Fresh garlic extract inhibits Staphylococcus aureus
  110. biofilm formation under chemopreventive and chemotherapeutic conditions, Songklanakarin
  111. Journal of Science and Technology, 38(4), 381–389.
  112. Salima, J., 2015. Antibact Erial Activity of Garlic, J Majority, 2 (4), 30–39.
  113. Sana Mukhtar, I.G., 2012, Antibacterial Activity of Aqueous and Ethanolic Extract of Garlic,
  114. Cinnamon and Turmeric Against Escherichia coli ATCC 25922 and Bacillus subtilis DSM
  115. , Thesis, Department of Environmental Sciences , Fatima Jinnah Women University,
  116. –136.
  117. Santhosha, S.G., Jamuna, P., Prabhavathi, S.N., 2013, Bioactive components of garlic and their
  118. physiological role in health maintenance: A review, Food Bioscience, 3, 59–74.
  119. Sieniawska, E., 2015, Activities of tannins-From in Vitro studies to clinical trials, Natural Product
  120. Communications, 10(11), 1877–1884.
  121. Simaremare, A.P.R., 2017, Perbedaan Aktivitas Antibakteri Ekstrak Tanaman Bawang Merah
  122. (Allium cepa L ) dan Bawang Putih ( Allium sativum L ) pada Berbagai Konsentrasi terhadap
  123. Bakteri Staphylococcus aureus In Vitro, Nommensen Journal of Medicine, 3(2), 52–57.
  124. Å krovánková, S., MlÄek, J., Snopek, L., Planetová, T., 2018,. Polyphenols and antioxidant capacity
  125. in different types of garlic. Potravinarstvo Slovak Journal of Food Sciences, 12(1), 267–272.
  126. Soltan, H.R., 2016, Extracted by Hydro-Distillationand Diethyl Ether Extraction Methods on Four
  127. Pathogenic Bacteria. Advances in Plants & Agriculture Research, 4(2), 261–264.
  128. Strika, I., Bašić, A., Halilović, N., 2017, Bulletin of the Chemists and Technologists of Bosnia and
  129. Herzegovina Antimicrobial effects of garlic ( Allium sativum L.). Organic scientist, 47, 1-10.
  130. Uzun, L., Dal, T., Kalcioglu, M.T., Yurek, M., Cibali Acikgoz, Z., Durmaz, R., 2019,
  131. Antimicrobial Activity of Garlic Derivatives on Common Causative Microorganisms of the
  132. External Ear Canal and Chronic Middle Ear Infections. Turkish Archives of
  133. Otorhinolaryngology, 57(4), 161–165.
  134. Viswanathan, V., Phadatare, A., Mukne, A., 2014, Antimycobacterial and antibacterial activity of
  135. Allium sativum bulbs. Indian Journal of Pharmaceutical Sciences, 76(3), 256–261.
  136. Wallock-Richards, D., Doherty, C.J., Doherty, L., Clarke, D.J., Place, M., Govan, J.R.W.,
  137. Campopiano, D.J., 2014, Garlic revisited: Antimicrobial activity of allicin-containing garlic
  138. extracts against Burkholderia cepacia complex. PLoS ONE, 9(12), 1–13.
  139. Wolde, T., Kuma, H., Trueha, K., Yabeker, A., 2018, Anti-Bacterial Activity of Garlic Extract
  140. against Human Pathogenic Bacteria. Journal of Pharmacovigilance, 06(01), 1–5.
  141. Xie, Y., Yang, W., Tang, F., Chen, X., Ren, L., 2014. Antibacterial Activities of Flavonoids:
  142. Structure-Activity Relationship and Mechanism. Current Medicinal Chemistry, 22(1), 132–
  144. Yadav, S., Trivedi, N., Bhatt, J., 2015. Antimicrobial activity of fresh garlic juice: An in vitro
  145. study. AYU (An International Quarterly Journal of Research in Ayurveda), 36(2), 203.
  146. Yetgin, A., Canli, K., Altuner, E.M., 2018. Comparison of Antimicrobial Activity of Allium
  147. sativum Cloves from China and Taşköprü, Turkey. Hindawi, 1-5.