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Submitted
April 27, 2023
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December 23, 2023
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Abstract

Ramipril merupakan antihipertensi golongan Angiotensin Converting Enzym (ACE) inhibitor yang termasuk ke dalam BCS kelas II dengan karakteristik kelarutan rendah dan permeabilitas tinggi dalam gastrointestinal. Kelarutan obat yang rendah akan berakibat disolusi berjalan lambat, sehingga absorpsinya eratik dan bioavailabilitasya rendah. Diperlukan upaya untuk meningkatkan disolusi sehingga peningkatan bioavailabilitas ramipril dapat tercapai. Penelitian ini bertujuan untuk mengetahui karakteristik dan disolusi tablet likuisolid ramipril. Tablet likuisolid ramipril 10 mg dibuat menggunakan pelarut PEG 400, propilenglikol dan Tween 80 dan adsorben Neusilin-Aerosil 200. Semnilan formula telah dikembangkan dan dievaluasi parameter prakompresi seperti daya alir dan juga parameter paska kompresi. Semua formula sistem likuisolid yang dikembangkan menunjukkan aliran yang baik sesuai data standar. Semua tablet likuisolid memenuhi karakteristik tablet yang baik meliputi keseragaman bobot, kekerasan, kerapuhan dan waktu hancur serta kandungan zat aktif. Uji disolusi dalam medium dapar fosfat pH 6,8 menunjukkan semua formula mampu melepaskan zat aktif lebih dari 80% pada menit ke-30 dan nilai DE30 lebih besar dibandingkan dengan tablet konvensional yang dibuat tanpa sistem likuisolid.

Keywords

dissolution liquisolid ramipril

Article Details

Author Biographies

Nailatul Husna, Universitas Wahid Hasyim

Farmasetika dan Teknologi Farmasi

Yulias Ninik Windriyati, Universitas Wahid Hasyim

Farmasetika dan Teknologi Farmasi

References

  1. Alhasani, K.F, Kazi M, Ibrahim, M.A, Shahba, A. A, Alanazi, F.K. (2019) ‘Self-nanoemulsifying ramipril tablets: A novel delivery system for the enhancement of drug dissolution and stability’, International Journal of Nanomedicine, 14, pp. 5435–5448. Available at: https://doi.org/10.2147/IJN.S203311.
  2. BPOM RI. (2011) ‘Obat Wajib Uji Ekivalensi’, Badan Pengawas Obat dan Makanan Republik Indonesia.
  3. Budiman, M.F. (2019) ‘Preparasi dan Karakterisasi Tablet Liquisolid Ramipril’, Tesis, Sekolah Farmasi Institut Teknologi Bandung.
  4. Dhall, M., Phaugat, P. and Nishal, S. (2019) ‘Studies on refined liquisolid system for simultaneous improvement of content uniformity and dissolution profile of glimepiride’, International Journal of Applied Pharmaceutics, 11(4), pp. 396–405. Available at: https://doi.org/10.22159/ijap.2019v11i4.33025.
  5. FDA. 2011, ‘Tablet Ramipril’, Food and Drug Administration, https://www.accesdata.fda.gov/drugsatfda_docs/label/2011/022021s007lbl.pdf, Diakses pada 2 Juli 2021
  6. Kemenkes RI. (2020) ‘Farmakope Indonesia Edisi VI’, Kementerian Kesehatan Republik Indonesia.
  8. Hay, A.M.A.El. and Adawy, Sh.A.El. (2017) ‘Enhancement of Dissolution Rate of Ramipril Tablets by Solid Dispersion Technique’, IOSR Journal of Pharmacy and Biological Sciences, 12(03), pp. 55–62. Available at: https://doi.org/10.9790/3008-1203015562.
  9. Jayapal, N. and Vamshi V. Y. (2021) ‘Formulation and In Vivo Evaluation of Self-Nanoemulsifying Drug Delivery System of Ramipril in Wistar Rats’, Asian Journal of Pharmaceutical and Clinical Research, 14(7), pp. 126-136. Available at: https://doi.org/10.22159/ajpcr.2021v14i7.42003.
  10. Kawabata, Y., Wada, K., Nakatani, M., Yamada, S., Onoue, S. (2011) ‘Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications’, International Journal of Pharmaceutics. Elsevier B.V., pp. 1–10. Available at: https://doi.org/10.1016/j.ijpharm.2011.08.032.
  11. Kumar, I., Verma, S. and Chaudhary, A. (2020) ‘Formulation of Ramipril Tablets Containing Solid Dispersion Employing Selective Polymers to Enhance Dissolution Rate’, Journal of Drug Delivery and Therapeutics, 10(3-s), pp. 142–149. Available at: https://doi.org/10.22270/jddt.v10i3-s.4109.
  12. Nirmala, M.J., Allanki, S., Mukherjee, A., Chandrasekaran, N. (2013) ‘Enhancing The Solubility of Ramipril Using a New Essential Oil Based Microemulsion System’, International Journal of Pharmacy and Pharmaceutical Science. 5(4), pp.322-323
  13. Santosh Kumar, R. and Sai, J.D. (2019) ‘Liquisolid Compacts: A Review’, Journal of Drug Delivery and Therapeutics, 9, p. 4. Available at: https://doi.org/10.22270/jddt.v9i4-A.3706.
  14. Shafiq, S., Shakeel, F., Talegaonkar, S., Ahmad, F.J., Khar, R.K., Ali, M. (2007) ‘Development and bioavailability assessment of ramipril nanoemulsion formulation’, European Journal of Pharmaceutics and Biopharmaceutics, 66(2), pp. 227–243. Available at: https://doi.org/10.1016/j.ejpb.2006.10.014.
  15. Shahba, A.A.W., Sherif, A., Ellzayat, E.M., Kazi, M. (2022) ‘Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs)’, Pharmaceuticals, 15(9). Available at: https://doi.org/10.3390/ph15091120.
  16. Siju, V.V., and Soniwala, M. (2017) ‘Liquisolid Compact: A New Technology for Optimization of Paliperidone Tablets by Central Composite Design’, International Journal of Pharmaceutical Sciences Review and Research, 45(1), pp.11-17
  17. Spireas, S. (2002) ‘Liquidsolid System and Methods of Preparation Same’, Pharmaceutical Research, 9, pp. 1-6.
  18. Suryawanshi, V. K., Gidwani, B., Verma, A., Dubey, N., Kaur, C. D. (2019) ‘Formulation and Evaluation of Ramipril Liquisolid Compact Using Novel Carrier’, International Journal of Pharmaceutical Sciences and Research, 10(2), pp. 917–925. Available at: https://doi.org/10.13040/IJPSR.0975-8232.10(2).917-25.
  19. Venkatesh, N., Thapa, A., Goti, S., Awari, V.P., Kalro, K.D. (2016) ‘Dissolution enhancement of ramipril using water soluble carrier by solid dispersion technology’, Journal of Pharmacy Research, 5(7), pp. 3561–3566. Available at: http://jprsolutions.info.
  20. Vraníková, B., Gajdziok, J. and Vetchý, D. (2015) ‘Modern evaluation of liquisolid systems with varying amounts of liquid phase prepared using two different methods’, BioMed Research International, Available at: https://doi.org/10.1155/2015/608435.
  21. Wang, D. et al. (2017) ‘Liquisolid technique and its applications in pharmaceutics’, Asian Journal of Pharmaceutical Sciences, pp. 115–123. Available at: https://doi.org/10.1016/j.ajps.2016.09.007.